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Pharmacological Effects of CBD

Cannabidiol (CBD) is a phytocannabinoid found in the cannabis sativa plant. It was discovered in 1940 and has undergone extensive clinical research ever since. Unlike THC, it’s not psychoactive (it won’t get you high), yet it exerts a plethora of beneficial pharmacological effects. Today, there are millions of CBD-infused products out there. The biggest difference between them is the speed of delivery and how long the effects last. For example, vapes work quickly but don’t last long, while tinctures take much longer, but can last all day. CBD has grown in popularity recently and I hope that I am able to provide you with some helpful information to help you decide whether it may be right for you.

There is a lot of research that supports CBD products in treating all kinds of pain, lowering inflammation, reducing anxiety, and improving sleep. I personally use CBD from Kronic Releaf. What’s even more incredible is that their products contain other ingredients like Himalayan Pink Salt, Olive Oil, Bees Wax, Aloe Vera Extract, and Turmeric Root Extract which have their own set of tremendous benefits and work in synergy with CBD.

It’s also used to treat several very serious illnesses and the effects including:

 

Type 1 Diabetes and Diabetic Complications

CBD exerts beneficial actions against diabetes and some of its complications. The anti-inflammatory, antioxidant and neuroprotective actions of CBD could contribute to these protective effects (Izzo et al., 2009). CBD is known for its presumed anti-inflammatory, pain-relieving and calming effects. Some reasons that people with type one diabetes are utilizing CBD include:

  • Type one diabetes-related anxiety
  • Peripheral neuropathy/chronic nerve pain
  • Reducing insulin resistance
  • Lowering cholesterol and risk of cardiovascular complications
  • General anti-inflammatory purposes

 

Cancer

There’s substantial evidence supporting the idea that cannabinoids can decrease tumor growth in animal models of cancer (Velasco et al., 2016). Additionally, according to the National Cancer Institute, CBD may also enhance uptake or increase the potency of certain drugs used to treat cancer.

CBD has shown interesting pro-apoptotic properties in cancer cell lines. The most studied phytocannabinoid is CBD. CBD induces increases in [CA2+]I, thereby stimulating ROS production and causing apoptosis. In vivo, CBD inhibits glaucoma growth and experimental breast carcinoma (Izzo et al., 2009)

 

Psychosis

Research on the effects of CBD has been undertaken for many neuropsychiatric conditions. CBD is the only cannabinoid to have been evaluated for possible antipsychotic effects. Izzo et al. (2009) suggest that it exerts antipsychotic actions and is associated with fewer adverse effects compared with “typical antipsychotics.”

 

Epilepsy

An experimental study (Devinsky et al., 2018) has also suggested that CBD exerts anti-epileptic actions. The FDA recently approved the use of Epidiolex (a plant-based formulation of CBD) to treat seizures for people 2 years of age and older with Dravet syndrome and Lennox-Gastaut syndrome (LGS).

 

Bone Formation

Research suggests that CBD as well as D9-THCV (via CB1 antagonism) have been suggested to exert anti-epileptic actions in experimental studies.

Standard medication has adverse effects on the body over time and you will eventually build a tolerance— requiring more and more for the same response. However, of 132 acute and chronic studies in humans reviewed by Bergamaschi et al., none reported a tolerance to CBD, and all described an impressive safety profile for a wide array of side effects.

 

Many people question whether CBD is safe to use, due to it being found in marijuana, which is still federally illegal as of this time. But the experts are really excited for the possibilities that it brings in treating patients and don’t think there is a risk of serious side effects, like other medications. A medical study (Iffland & Grotenhermen, 2017) confirmed its favorable safety profile. It was also determined that chronic use and high doses up to 1,500mg per day is well tolerated by humans.

I’m personally well-convinced of its safety and it’s positive effects. I also think that there are probably multiple readers who stand to benefit from giving it a try. If you have any further questions about CBD use, feel free to leave a comment and I’ll be happy to try and point you in the right direction.

 

 

References:

Bergamaschi, M. M., Queiroz, R. H. C., Chagas, M. H. N., de Oliveira, D. C. G., De Martinis, B. S., Kapczinski, F., Quevedo, J., Roesler, R., Schröder, N., Nardi, A. E., Martín-Santos, R., Hallak, J. E. C., Zuardi, A. W., & Crippa, J. A. S. (2011). Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients. Neuropsychopharmacology, 36(6), 1219–1226. https://doi.org/10.1038/npp.2011.6

Cannabis and Cannabinoids (PDQ®)–Health Professional Version. (2020, November 6). National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/cam/hp/cannabis-pdq

Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome. (2018). The New England Journal of Medicine. https://www.nejm.org/doi/10.1056/NEJMoa1714631

Iffland, K., & Grotenhermen, F. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and Cannabinoid Research, 2(1), 139–154. https://doi.org/10.1089/can.2016.0034

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. (2009). Trends in Pharmacological Sciences, 30(12), 609. https://doi.org/10.1016/j.tips.2009.10.007

The use of cannabinoids as anticancer agents. (2016, January 4). ScienceDirect. https://www.sciencedirect.com/science/article/pii/S0278584615001190?via%3Dihub

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